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for reviewing the manuscript, and Stephen Purver of Axis, a division of Spirit Medical Communications Group Limited, for assistance with medical writing and editorial support (funded by Novo Nordisk A/S)

pH activity profiles Appropriate dilutions of purified laccase variants were prepared such that 10-l aliquots of enzymes in reaction mix gave rise to a linear response in kinetic mode for each substrate assayed

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Half of the studies reported a reduction in the risk of the composite outcome, similar to the add-on therapy or simultaneous use of the medications

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