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With that in mind here are the injection sites you can use on your body for B12 shots: Mid-thigh (right into your quadriceps): This is the preferred site if you are self-injecting

Step 5: Remove and Dispose Withdraw the needle at the same angle of insertion

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Here are some general guidelines to consider: Initial Treatment: For those with a significant deficiency, weekly injections may be recommended initially to rapidly build up Vitamin B12 levels