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These findings highlight the need for cautious use and thorough reporting of gallbladder-related adverse events in future trials and in the post-marketing setting

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Many toxicologists would recommend repeating the measurements of alanine aminotransferase and acetaminophen concentrations as the patient approaches the end of the 16-hour infusion period and continuing treatment if the alanine aminotransferase concentration is elevated or if the acetaminophen concentration is measurable

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Taken together, these in vivo data from multiple CRC models support our conclusion that inhibition of mitochondrial metabolism by metformin treatment can enhance the response of 5FU treatment by increasing tumour cell death and impeding tumour growth