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Evaluation of growth hormone (GH) action in mice: discovery of GH receptor antagonists and clinical indications

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For the tirzepatideGIPRG s and non-acylated tirzepatideGIPRmini-G s complexes, GIPR and DNG s or mini-G s heterotrimer were co-expressed in High Five cells

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On average, patients who took 12 mg doses lost 11.5 lbs, or 5.8% of their body weight, while patients who were administered 36 mg doses lost 15.8 lbs, or 7.6% of their body weight