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Systemic administration of fluorescently labeled tirzepatide in rodents resulted in labeling of the median eminence, area postrema, and other circumventricular organs in the brain, indicating one route of how tirzepatide may access parts of the brain to exert its effects [67]

doi: 10.1161/CIRCULATIONAHA.119.044703 243 GaldieroMRMorelliETriggianesePCarucciLPunzianoAPintoAet al

The FDA-approved maintenance doses are 5 mg, 10 mg, and 15 mg