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Among studied drugs (Efavirenz, Tenofovir, Emtricitabine, Lamivudine, and Indinavir), only Efavirenz increased ER stress via upregulation and activation of the inositol requiring kinase 1 (IRE1) and protein kinase-like ER kinase (PERK) signaling

Upon start, satellite cells proliferate and differentiate into myoblasts, which can either fuse with existing muscle fibers to increase their size or fuse with each other to form new muscle fibers, a process called hyperplasia

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Active malignancy warrants avoidance as discussed above