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For injectable GLP-1 medications, timing relative to levothyroxine is less critical since the interaction occurs through general effects on gastric emptying rather than direct simultaneous absorption

I know this sounds a bit gruesome, but one can find in the historical medical literature

Lixisenatide is a long-lasting GLP-1R agonist that crosses blood-brain barrier at very low doses (Hunter and Holscher, 2012)

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