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Adv Exp Med Biol (2015) 869:2554

This suggests that levels of free heme alone are not sufficient to immediately change the oxidative state of the parasite, although it is recognised that chemical inhibition of cysteine proteases may have additional impacts on the parasite, and does not perfectly mimic the heme depletion caused by K13-mediated alteration of hemoglobin uptake

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Individual compounds provide flexibility researchers can adjust ratios, study compounds independently, and design custom combinations

Selenium Deficiency: Large areas of Australia are known to be selenium deficient