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Dziewierz A, Rajtar-Salwa R, Pelliccia F

Figure 5: ACE2 degrades des-argBKN (BK1R) and ACE degrades BKN (BK2R) ? ACE and ACE2 are neuroprotective

J Control Release 343:443456 Mahmood I, Balian JD (1999) The pharmacokinetic principles behind scaling from preclinical results to phase I protocols

In other subgroups, amycretin weekly maintenance at 20 mg, 5 mg, or 1.25 mg resulted in 22%, 16.2%, and 9.7% weight loss, respectively, compared to 1.92.3% weight gain in the placebo group (Table 1) [42]