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By engaging these complementary pathways, mazdutide represents an alternative approach to incretin-based therapy beyond GLP-1 monotherapy
Despite ameliorated glycemic control, while both GLP-1Ra and SGLT-2i demonstrated reduced atherosclerosis-related events, only the latter showed a significant impact on HF incidence and hospitalization, reflecting the effects on the myocardium that the two drug classes possess
In states of obesity and metabolic dysfunction, NNMT is often overexpressed in adipose tissue, depleting nicotinamide and reducing NAD+ availability [2]
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