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Reported side effects have been gastrointestinal symptoms, such as nausea, vomiting, diarrhea, constipation, and abdominal discomfort

Many extended health benefit plans cover Mounjaro for diabetes but exclude or limit weight management coverage

Insulin: Common side effects: Hypoglycemia, weight gain

Diet and Exercise Strategies That Amplify Results Retatrutide creates a powerful window for weight loss, but nutrition and movement choices determine whether you lose primarily fat while preserving muscle, or sacrifice lean tissue along with unwanted pounds

Some researchers find the larger injection volumes less comfortable, especially for daily protocols, though retatrutide is administered weekly which makes this less of a concern