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10.1002/sctm.18-0009 Stem Cells Transl

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Abbreviations CNS: Central Nervous System EEG: Electroencephalogram ILAE: International League Against Epilepsy DRE: Drug-Resistant Epilepsy AEDs: Anti-Epileptic Drugs HDAC: Histone Deacetylase HDACi: Inhibitors of HDACs DVPX: Divalproex Sodium SIRT: Sirtuin NAD + : Nicotinamide Adenine Dinucleotide MAP: Mitogen-Activated Protein MKP1: MAP Kinase Phosphatase 1 MAPK: MAP Kinase SMRT: Silencing Mediator for Retinoid and Thyroid Receptors N- CoR: O- Nuclear Receptor Corepressor LPS: Lipopolysaccharide STAT1: Signal Transduction and Activation Of Transcription 1 NF-B: Nuclear Factor B MDM2: Murine Double Minute 2 ISG: IFN-Stimulated Gene MEF2: Myocyte Enhancer Factor-2 Hsp90: Heat Shock Protein 90 SUMO: Small Ubiquitin-Like Modifier ZXD: Zinc finger X-linked Duplicated ZXDC: ZXD Family Zinc Finger C PML: Promyelocytic Leukemia Protein SCFA: Short Chain Fatty Acid IEG: Immediate Early Gene BDNF: Brain-Derived Neurotrophic Factor PP2A: Phosphatase 2 A RGC: Retinal Ganglion Cell GABA: Gamma-Aminobutyric Acid SRF: Serum Response Factor HS: Hippocampal Sclerosis MTLE-HS: Mesial Temporal Lobe Epilepsy with Hippocampal Sclerosis PGC-1: Proliferator-Activated Receptors and coactivator 1 VPA: Valproic Acid LCM: Lacosamide Bsn: Bassoon Gene TSC2: Tuberous Sclerosis Complex 2 NaB: Sodium Butyrate TSA: Trichostatin A GluR2: Glutamate Receptor 2 SAHA: Vorinostat GABRG2: A Type GABA receptor 2 FDA: Food and Drug Administration EMA: European Medicines Agency BBB: Blood-Brain Barrier PROTAC: Proteolysis Targeting Chimera References Thijs RD, Surges R, OBrien TJ, Sander JW

It helps to protect cells from oxidative damage, which can lead to chronic diseases and aging

Nitric oxide signalling underlies salicylate-induced increases in neuronal firing in the inferior colliculus: a central mechanism of tinnitus