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Published January 2021 in the journal PNAS , a collaborative research team out of Johns Hopkins University School of Medicine and the University of Exeter in the United Kingdom developed a novel way to slowly deliver just the right amount of hydrogen sulfide, improving various aspects of Alzheimers disease in mice

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Switching from Injectable to Oral# Recommendation : Orforglipron Reason : ATTAIN-MAINTAIN showed that patients switching from injectable semaglutide or tirzepatide to oral orforglipron maintained their previously achieved weight loss, validating oral step-down therapy

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Administered once daily without dietary restrictions, orforglipron demonstrated significantly improved bioavailabilityapproximately 20%-40% in preclinical modelscompared to the substantially lower bioavailability of oral semaglutide, which ranges from just 0.4% to 1% and requires fasting for adequate systemic exposure,