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In November 2023, tirzepatide for chronic weight management was approved as Zepbound, with SURMOUNT trial data showing mean weight loss of roughly 21% at the 15 mg dose over 72 weeks

[34] examined how these medications affect cancer risk in people with obesity in a population-based study of over 1.1 million patients

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The corresponding metabolitegene interaction pairs underlying ASDcontrol differences are summarized in Supplementary Table S3

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