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DISCUSSION Only recently has there been evidence that L-carnitine content in skeletal muscle can be increased when supplementation is coincided with a strong insulin response (25, 31)

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GLP-1s may not cure Alzheimers as a monotherapy, but they are reshaping how we think about the interface of neurodegenerative disease etiology, metabolic health, vascular function and they likely will cement themselves as foundational tools in delaying cognitive decline across aging populations

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Enhancing Insulin Sensitivity Metformin also plays a crucial role in improving insulin sensitivity in peripheral tissues, such as muscle and fat cells