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For the BP-AD, AMX-AD, OXA-AD and MEZ-AD groups, 134, 177, 104 and 123 unique differential features meeting the threshold requirements were selected (black rectangle in Fig

CRISPR guide RNAs were designed using CHIRPOR.org 42 and were used as two-part synthetic crRNA and tracrRNA (Alt-RTM CRISPR guide RNA, Integrated DNA Technologies, Inc)

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