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Ceramide NP (formerly known as Ceramide 3) is one of the skin's naturally occurring lipids

A reference biologic with no biosimilar development programs underway at the start of a patent expiry window (the biosimilar void observed in roughly 90% of biologics approaching LOE) faces a very different revenue erosion curve than one with five filed BLAs and two already-approved biosimilars

Someone taking a quarter of the starting dose isnt getting a gentler version of the drug they may be getting something closer to a placebo, at least for their metabolic condition

however, releasing the skin too quickly before the injection is completed or lifting it incorrectly can increase that risk (Down and Kirkland, 2012)