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And the operating margin, which had been a slim positive 0.1% in 2024, dropped to -4.3% in 2025

2 The primary risk factor for gout is elevated levels of a metabolic byproduct called uric acid in the blood

If you have any of the following, make sure to talk about it with your doctor: A history of pancreatitis Severe gastrointestinal diseases You are pregnant or breastfeeding A personal or family history of medullary thyroid cancer or multiple endocrine neoplasia If youre undergoing surgery, you may need to stop taking GLP-1 beforehand

TABLE 1 Clinical trials evaluating oxidative stress-related interventions in MI

If you are of childbearing potential, discuss appropriate contraception with your provider and consider discontinuing semaglutide at least 2 months before a planned pregnancy due to its long half-life