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Eligibility criteria vary, and participation requires informed consent and regular clinical monitoring

Patients usually begin with a lower dose such as 0.25 mg for the first four weeks, then increase to 0.5 mg to allow the body to adjust to the medication before moving to higher maintenance doses if needed

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The AKT-induced phosphorylation of FoxO proteins generates the binding sites for the 14-3-3 proteins which induce the accumulation of FoxO proteins into the cytoplasm thus preventing their transcriptional activity