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Semaglutide can affect your central nervous system because it can cross the blood-brain barrier to affect areas of the brain involved in appetite regulation and nausea perception, potentially contributing to nausea and even vomiting

In all the CV outcome trials there was very modest impact on weight that could not have contributed to the CV benefits

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In addition, these medications may help to reduce the risk of developing other obesity-related health conditions such as fatty liver disease, sleep apnea, and joint problems

Anecdotal reports suggest potentially stronger effects, but without controlled comparisons, this remains speculative