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An RNAi therapeutic targeting Tmprss6 decreases iron overload in Hfe(-/-) mice and ameliorates anemia and iron overload in murine beta-thalassemia intermedia

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Knockdown of GCH1 significantly activated ferritin autophagy upon erastin treatment, which was reversed by using an autophagy inhibitor

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In the circulation, GH is bound to the high affinity GH binding protein (GHBP), which is generated by proteolytic cleavage of the cell membrane-bound GH receptor (GHR)

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