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Enzyme-responsive drug delivery system has been demonstrated, which consist of triblock N-(2-hydroxypropyl methyl) acrylamide (HPMA) conjugated with tetrapeptide linker, which allows the high molecular weight (92 kDa) to degrade into low molecular weight (44 kDa) and deliver the paclitaxel drug at tumor site [54]

While the Independent Assessor did not consider the PPS progress through DY2, Q2, PPS were able to use the progress that had been demonstrated through their DY2, Q2 PPS Quarterly Report to support their responses to the Independent Assessor recommendations or as the basis for the PPS recommendations submitted to the Independent Assessor