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[Abstract]2025 May 1;66(5):19

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Indeed, over 110 different compounds, including metals, their oxides, metal salts, drugs, kinase inhibitors, endogenous toxins, inhibitors of signaling pathways, alkaloids and other plant-derived biologically active substances, have been shown to induce eryptosis in vitro at lower concentrations than hemolysis or to a higher extent at the same concentrations [450]

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Richer skin tones carry a higher risk of post-inflammatory hyperpigmentation, which makes treatment selection and intensity a genuinely clinical decision one reason a barrier-conscious, formula-led approach is often preferred over aggressive resurfacing for pigment-prone skin