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Notably, organelles-mediated mechanisms seem to play an important and multifunctional role in ferroptosis execution and mediate the crosstalk between ferroptosis and other RCDs like apoptosis [172]

This review concluded that intakes up to 2 g/day are safe for chronic supplementation. An International Olympic Committee (IOC) statement on dietary supplements for high-performance athletes stated that No negative health effects are noted with long-term use of creatine

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