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Retatrutide: A Promising Option for Non-Diabetic Weight Loss in Clinical Trials Key Takeaways Retatrutide, a new triple receptor agonist, appears particularly promising as a non-diabetic weight loss agent because it targets glucagon, GLP-1, and GIP
Retatrutide is not yet approved by Health Canada for clinical use
The FDA wants to see actual resolution of liver inflammation and fibrosis improvement, not just fat reduction
One thing is that, in trials, some of these new medications are increasing the amount of weight loss, but that means higher reward, higher risk, with more side effects, says John Morton, MD, MPH, chief of Yale Medicine Bariatric and Minimally Invasive Surgery and a board-certified obesity medicine specialist