While semaglutide should be safe for most people, it often causes gastrointestinal side effects early in treatment, including:8 Bloating Abdominal pain Nausea Vomiting Diarrhea Belching Flatulence While these arent the most pleasant or flattering side effects, they often fade with use as your body adjusts to the effects of the medication
Diabetes Med (2000) 17(1):339

Sources New England Journal of Medicine: TripleHormone-Receptor Agonist Retatrutide for Obesity A Phase 2 Trial New England Journal of Medicine: Once-Weekly Semaglutide in Adults with Overweight or Obesity Eli Lilly: News Release: Lillys phase 2 retatrutide results published in The New England Journal of Medicine Clinical Trials Arena: Eli Lilly infiltrates anti-obesity market as Phase III trial for retatrutide begins Eli Lilly: News Release: Lillys tirzepatide shows additional 21.1% weight loss after 12 weeks of intensive lifestyle intervention, for a total mean weight loss of 26.6% from study entry over 84 weeks FDA Label: OZEMPIC (Semaglutide Injection) Medication Guide FDA Label: WEGOVY (Semaglutide Injection) Medication Guide FDA Label: RYBELSUS (Oral Semaglutide) Medication Guide FDA Label: MOUNJARO (Tirzepatide Injection) Medication Guide FDA Label: ZEPBOUND (Tirzepatide Injection) Medication Guide Important Medical Information and Disclaimers Medical Disclaimer This article, Will Retatrutide Be Available in 20262027?, is for educational purposes only and is not intended to replace professional medical advice, diagnosis, or treatment

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Effect of Subcutaneous Semaglutide vs Placebo as an Adjunct to Intensive Behavioral Therapy on Body Weight in Adults With Overweight or Obesity