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The FDA requires a CVOT for all antidiabetic agents per its 2008 guidance, and a GLP-1-class CVOT is standard for obesity agents following SELECT (semaglutide 2.4 mg, N=17,604) which showed a 20% reduction in MACE [11]

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Semaglutide is the active ingredient in three popular medications: Wegovy, Ozempic, and Rybelsus.[5-7] While all three contain semaglutide, only Wegovy is approved by the U.S