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While hydroxocobalamin is not already methylated, it is readily converted to this form to support the methylation cycle

Moreover, higher concentrations of several chemokines, such as CCL2 and CXCL8, were detected in the serum and CSF of depressed patients (Sutcigil et al., 2007

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33 These compounds trigger the local production by macrophages and activated alveolar cells of inflammatory cytokines such as interleukin 6 and tumor necrosis factor and the potent vasoconstrictor endothelin 1