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A study found that Somaglutide freeze-dried powder is mainly produced through protease cleavage of the peptide skeleton and sequential fatty acid side chains Oxidation undergoes metabolism

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However, oral administration of peptide-based drugs is challenged by their degradation in the stomach due to low pH and proteolytic enzymes, and by their limited permeability across the gastrointestinal epithelium [4, 5]

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JAMA (2022) 327(2):13850