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Thus, they are supported by stringent Federal Drug Administration (FDA) guidelines ensuring their efficacy and safety [87]

Cell Biochemistry and Function, 22(6):343-52, doi: 10.1002/cbf.1149 Ballatori, N., Krance, S

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In addition to inducing HF by promoting atherosclerotic progression, elevated plasma TMAO levels may accelerate myocardial hypertrophy, exacerbate mitochondrial dysfunction, and induce transverse-tubule (T-tubule) remodeling in cardiomyocytes (93)

The downside is that, while Life Extension does list its sources, the company cites the journal and applicable page numbers, but doesnt name the study or article the information came from (knowing this information can make verifying the claims a bit easier)