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For many, these effects become weaker over time

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Neurochem Res 47(7):18531864 Cho JH et al (2021) Anti-inflammatory effects of melatonin: a systematic review and meta-analysis of clinical trials

[9] A standard ladder calibrated for the average trial participant will therefore overshoot for a meaningful share of women, delivering more weight loss than they wanted along with more nausea than anyone wants

This is evidenced when comparing photos of her from 2022 and 2024