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Each n represents a biological replicate from 34 independent cohorts of sex- and age-matched animals

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Also, experiments conducted in primary islet cells have shown that -arrestin1 restricts the insulin secretion response to GLP1R activation, but not to GIPR activation or tirzepatide

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Dosing tiers: Oral administration (500 mcg to 1.5 mg/day) targets gut-specific inflammation: IBD, colitis, and intestinal barrier dysfunction