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Ascorbate can be regenerated from its oxidized forms, monodehydroascorbate (MDHA) and dehydroascorbate (DHA), by MDHA and DHA reductases (MDHARs and DHARs), respectively (Smirnoff, 2018) The activity of DHARs is coupled to oxidation of glutathione, which is also required for spontaneous, non-enzymatic reduction of DHA to ascorbate (Figure 1)

[DOI] [PMC free article] [PubMed] [Google Scholar] 134.Caruso A., Gelsomino L., Panza S., Accattatis F.M., Naimo G.D., Barone I., Giordano C., Catalano S., Ando S

Xenobiotics (ie exogenous lipophilic substrates) are the major pathological source of electrophiles, by way of reactive xenobiotic species (RXS) that are inadvertently generated upon processing by cytochrome P450 monooxygenases (CYP)

Had the MRA, cortisone etc

Eur J Histochem EJH