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In Long COVID, this endothelial damage promotes immunothrombosis, the formation of microscopic blood clots (microclots) that block tiny capillaries and prevent oxygen from reaching vital tissues like the brain and muscles

Additionally, AGEs reduce NO production and inhibit histamine-induced NO production in ECs [172]

However, split-dosing protocols for similar incretin-based peptides show that dividing the dose does reduce peak blood levels by approximately 15-25%, which correlates with reduced gastrointestinal side effects in some individuals

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Supplements can be for single nutrients, such as vitamin D or iron, or multiple nutrients, such as a multivitamin