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(1) Given that osteoarthritis (OA) is the leading indication for arthroplasty and obesity is the most significant modifiable risk factor for OA development, it is unsurprising that a substantial proportion of arthroplasty patients are affected by obesity

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GLP-1 receptor agonists: weight loss as trigger, bioenergetics as outcome GLP-1 reduces appetite and weight, but the downstream cascade is bioenergetic, resulting in less ectopic fat (hepatic/visceral), reduced lipotoxicity, and relief of ER/mitochondrial stress across the liver, muscle, and heart

One of the key mechanisms behind its anti-inflammatory effects is its ability to reduce visceral fatthe fat surrounding internal organs