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For appropriate candidates, treatment may include Semaglutide or Tirzepatide as part of a comprehensive, medically supervised plan

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Effects of GLP-1R activation in the heart The observation that GLP-1 decreases contractility in primary culture of adult rat cardiomyocytes, despite increasing cAMP levels, [38] has also been reported in isolated rat hearts [45]

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Medical providers consider multiple factors when determining whether newer treatments are appropriate, including health history, weight loss goals, and tolerance to medication