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Approximately 60% of CagriSema-treated participants achieved at least 20% weight loss, and 40.4% achieved at least 25% loss, with some participants losing over 30% of body weight

ManteroPMatusGSCortiRECabanneAMZerbetto de PalmaGGMarchesi OlidLet al

To mitigate metabolic and physiological disparities, humanized zebrafish modelssuch as those with knock-in of the human CYP3A4 genecan be generated via CRISPR/Cas9

In addition, IDH1-dependent reductive glutamine metabolism produces NADPH, which decreases mitochondrial ROS during anchorage-independent growth 64

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