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Flavanones and flavones are usually found in the same fruits and are connected by specific enzymes while flavones and flavonols do not share this phenomenon and are rarely found together

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For example, a tri-functional copper-based MOF nanozyme developed by Dong et al.not only generates ROS but also modulates the redox environment, overcoming chemotherapy resistance in CRC and providing a new therapeutic strategy for future clinical applications [101]

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