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Concomitantly, local hypoxia, oxidative stress, and maladaptive ECM remodeling further exacerbate adipocyte dysfunction, underscoring the multifactorial nature of adipose tissue-driven metabolic derangement in T2DM [18]

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For hair loss, GHK-Cu dosage protocols often involve both systemic subcutaneous injection (1 to 2 mg/day) and localized scalp delivery via mesotherapy or microneedling with GHK-Cu solution