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The trade-off is that the analogue is a poor model of native IGF-I physiology precisely because it bypasses the buffering system that governs it

It is called Polymorphous light eruption

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IGF-1 LR3 is not appropriate for patients who are pregnant or breastfeeding, have active cancer or a cancer history (because IGF-1 stimulates cell growth broadly, including potentially malignant cells), have uncontrolled diabetes or diabetic retinopathy, or are under 21

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