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These disruptions lead to water and sodium influx, potassium efflux, cell swelling, membrane potential changes, and eventual cell lysis, which then releases intracellular contents, eliciting an inflammatory phenotype through DAMP release and triggering immune responses (Murao et al., 2021)

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Regular Physical Activity Combine resistance training and cardiovascular exercise to support metabolic health

Studies have shown that 1,25(OH)D enhances intercellular adhesion among keratinocytes by upregulating E-cadherin expression and inhibiting -catenin nuclear translocation, thereby stabilizing adherens junction complexes and reinforcing the integrity of tight junctions in the epidermis [222]

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