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Long-chain fatty acids must be esterified to L-carnitine (acylcarnitine) in order to enter the mitochondrial matrix where -oxidation occurs ( Figure 3 )

These advancements have greatly improved our understanding of molecular biomarkers associated with various diseases, facilitating early diagnosis and the development of targeted therapeutic strategies 18,21

Cleavable linkers possess functionalities susceptible to degradation through lysosomal processes (protease-sensitive, acid-sensitive, and reduction-sensitive)