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The nearly 300 participants were adults aged 18 to 75 who were obese or overweight and had at least one weight-related condition, excluding Type 2 diabetes, and weighed an average 240 pounds

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Paired-pulse stimulation (50 ms interpulse interval, 0.1 Hz) was used to calculate paired-pulse ratio (PPR, PS2/PS1), to estimate changes in the probability of transmitter release