Major weight loss affects the whole body, including the face, and can definitely impact volume in the jowls and cheeks, among other places. This is what Deneuve meant when she said one had to choose: when we lose a lot of volume in the body, our face can follow suit, aging our appearance
Lancet (2021) 398:58398
For example: People put on GLP-1 drugs might differ in meaningful ways from those started on SGLT-2s or DPP-4s Severity of diabetes, weight, blood pressure patterns, sleep apnea, smoking history, and other factors can be hard to capture perfectly in claims Diagnostic coding can be imperfect Follow up time was up to 18 months, not years That said, the study is large, and it tries to do the comparison thoughtfully
If 0.5mg is comfortable after two weeks, go to 1mg
It doesnt just perform one function