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In summary, melatonin, as a broad-spectrum antioxidant and modulator of mitochondrial activity, appears to be a promising approach for the treatment of many MQC-related injuries or diseases

Studies revealed that many COVID-19 patients had severely depleted glutathione stores, potentially contributing to the oxidative damage seen in serious cases

Nucl Med Biol 6465:3440 Liu Z, Wang J, Li Y, Fan J, Chen L, Xu R (2017) MicroRNA-153 regulates glutamine metabolism in glioblastoma through targeting glutaminase

Ethics declarations Ethics approval and consent to participate All procedures described herein were approved by the Institutional Review Board for the Protection of Human Subjects of Baylor University (Protocol # 7920244) and Research Ethical Review Committee of Kyowa Hakko Kirin Co., Ltd

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