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Medical Clearance Checklist Before Restarting Semaglutide Before resuming semaglutide, confirm with your surgeon that you meet these key readiness markers: you're eating solid foods without pain or significant nausea, you've stopped prescription opioid pain medications (or your surgeon cleared their use alongside GLP-1 therapy), and at least 48 hours have passed since your last dose of general anesthesia or sedation