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Sensitization can be quantified according to the degree of positive patch test reaction (+ to +++), patch test concentration threshold defined by dilution series, and finally by the "Use test"

In three-dimensional space, V730 is located near the coactivator binding site 84 and, along with M734 and I737 in the hydrophobic groove, allows the formation of a smoother and flatter surface that permits greater complementarity to FxxLF compared with the LxxLL motif (Figure 7C)

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