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K i values derived from nonlinear regression were 3.33 0.23 mM for GSH and 3.52 0.24 mM for CDNB, while corresponding values obtained from secondary plots were 2.84 mM for both substrates (Fig

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The conformation of TM6-ECL3-TM7 has been correlated with the distinct signalling profiles of GLP-1 and exendin-P5, and along with the conformation of TM1, TM2 and ECL2, are key receptor domains important for GLP-1R cAMP signalling, and biased agonism 3, 13, 28, 29