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the 2.4 mg dose produced 16.9%, only 3.7% more despite more than doubling the dose and significantly increasing GI side effects (Wilding et al., NEJM 2021)

Monitoring during tirzepatide therapy should include regular assessment of gastrointestinal tolerability, as severe nausea and vomiting can lead to dehydration and electrolyte disturbances that may indirectly affect cardiovascular stability

Another challenge is that small peptides are often broken down rapidly in the body

sadly, many patients develop severe fatal outcomes because of overwhelming inflammation known as cytokine storm (248, 249), that leads to ROS-mediated cell death and tissue damage typical of RNA viruses (250)

Ighodaro OM, Akinloye OA (2018) First line defence antioxidants-superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPX): Their fundamental role in the entire antioxidant defence grid