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Although Sanna S et al

Uses: Primarily used in skincare to reduce oxidative stress, brighten the skin, and manage pigmentation

This synthesis of vitamin B 12 is of no practical consequence due to its length, taking 72 chemical steps and giving an overall chemical yield well under 0.01%

However, the evidence is modest , especially for cosmetic uses like skin-whitening, and the side-effects , while usually mild, must be taken seriously especially in certain populations (asthma, pregnant, on chemotherapy, etc.)

An RCT combining NAC with pirfenidone found no additional lung function benefit but increased photosensitivity (142)